Launch from Cape Canaveral (KSC); landing on Cape Canaveral (KSC); ISS-19-12A ITS-P3 / ITS-P4.

Docking to ISS on 11.09.2006 and common work with the ISS expedition 13. The launch was scrubbed several times because of bad weather and technical problems. It was the first time in almost four years that a major new space station component, the 17.5-ton, bus-sized P3/P4 integrated truss section, has been launched.

First EVA by Tanner and Stefanyshyn-Piper on 12.09.2006 (6h 26m) for installation of power and data cables between the P1 and P3/P4 structures in preparation for solar array deployment.

Second EVA by Burbank and MacLean on 13.09.2006 (7h 11m) to continue work to prepare the International Space Station’s P3/P4 integrated truss for operation; MacLean became the first Canadian to perform an EVA.

Third and final EVA by Tanner and Stefanyshyn-Piper on 15.09.2006 (6h 42m) to perform final tasks required for activation of the Solar Alpha Rotary Joint (SARJ); the SARJ is an automobile-sized joint that will allow the station's solar arrays to turn and point toward the sun; they also prepared the P3/P4 truss and its solar arrays for operation by setting the stage for deployment of the truss' radiator; Tanner has performed than 7 EVA's in his career; later on the solar arrays were fully unfolded; Stefanyshyn-Piper retrieved the materials on the International Space Station Experiment 5; the materials science experiment tests the effects of the space environment on prospective spacecraft materials.

Other work of the crew were: a talk of MacLean with the Canadian Prime Minister Stephen Harper and other press meetings, transferring cargo, including water, between the shuttle and the space station, removal of the REBA, Rechargeable EVA Battery Assembly, photo shootings

After undocking from the ISS, the heat shield was inspected; additional inspections were necessary, when a video from cameras aboard the shuttle showed a piece of debris in close proximity to the vehicle, but engineers found no issues of concern during the survey.