Launch from Cape Canaveral (KSC); landing on Cape Canaveral (KSC). This was the sixth mission to the ISS.

During the 11-day mission, the primary objective was completed, which was to deliver and connect the first set of U.S.-provided solar arrays to the International Space Station. The astronauts completed three spacewalks, during which they prepared a docking port for arrival of the Destiny Laboratory Module, installed Floating Potential Probes to measure electrical potential surrounding the station, installed a camera cable outside the Unity Module, and transferred supplies, equipment and refuse between Endeavour and the station

Following a two day solo flight the Endeavour docked with the ISS on December 02, 2000. During the next seven days the crew performed common work with the first expedition of the ISS.

The first EVA by Joseph Tanner and Carlos Noriega was performed on December 03, 2000 (7h 33m). They performed preparation work for the mount of the energy module and checked the docking to Z1.

The second EVA by Joseph Tanner and Carlos Noriega occured on December 05, 2000 (6h 37m). The astronauts connected electric power cables between the new P6/Z1 and the module Unity. The port wing successfully spread after the second spacewalk.

The third and final EVA was conducted by Joseph Tanner and Carlos Noriega on December 07, 2000 (5h 10m). First they had to repair a solar paneel. Later they installed Floating Potential Probes to measure electrical potential surrounding the station, installed a camera cable outside the Unity Module

After that the crew of the Endeavour turned over to the ISS and its current resident crew (December 08, 2000). Until then the shuttle and the station had kept one hatch closed to maintain respective atmospheric pressures, allowing the shuttle crew to conduct their spacewalks and mission goals. After a welcome ceremony and briefing, the eight spacefarers conducted structural tests of the station and its solar arrays, transferred equipment, supplies and refuse back and forth between the spacecraft, and checked out the television camera cable installed by Joseph Tanner and Carlos Noriega for the upcoming mission.

On December 09, 2000 the two crews completed final transfers of supplies to the station and other items being returned to Earth. The Endeavour crew bade farewell to the first expedition at 10:51 EST and closed the hatches between the spacecraft. After being docked together for 6 days, 23 hours and 13 minutes, Endeavour undocked from the station