ISS: Expedition 3

Launch from Cape Canaveral; landing on Cape Canaveral (KSC).

Following a two day solo flight the Discovery docked with the ISS on August 12, 2001. The crew replaced the expedition 2 crew. The main purpose of STS-105 was the rotation of the International Space Station crew and the delivery of supplies utilizing the Italian built Multi Purpose Logistics Module (MPLM) Leonardo on its second flight.

The first EVA by Vladimir Dezhurov and Mikhail Tyurin occured on 08.10.2001 (4h 58m) using first time the new Russian built airlock and docking port named Pirs, which docked on the Zvezda module since September 2001.

The second spacewalk was performed by Vladimir Dezhurov and Mikhail Tyurin on October 15, 2001 (5h 52m) to mount a variety of instruments outside the Zvezda service module.

The third EVA by Vladimir Dezhurov and Frank Culbertson was conducted on November 12, 2001 (5h 4m) to connect seven cables between Zvezda service module and Pirs docking module and take photos.

The fourth and final EVA was performed by Vladimir Dezhurov and Mikhail Tyurin on December 03, 2001 (2h 46m) to cut away a rubbery O-ring seal that was preventing an unmanned cargo freighter from properly docking to the complex.

The crew carried home the results of following experiments: Advanced Protein Crystallization Facility, the Dynamically Controlled Protein Crystal Growth experiment and cells from the Cellular Biotechnology Operations Support System (CBOSS).

During the stay on board of the ISS the crew of expedition 3 carried out the following scientific experiments:
APCF-Camelids (Advanced Protein Crystallization Facility - Extraordinary Structural Features of Antibodies from Camelids),
APCF-Crystal_Growth (Advanced Protein Crystallization Facility - Solution Flows and Molecular Disorder of Protein Crystals: Growth of High Quality Crystals, Motions of Lumazin Crystals and Growth of Ferritin Crystals),
APCF-Crystal_Quality (Advanced Protein Crystallization Facility - Effect of Different Growth Conditions on the Quality of Thaumatin and Aspartyl-tRNA Synthetase Crystals Grown in Microgravity),
APCF-Lipoprotein (Advanced Protein Crystallization Facility - Crystallization of Human Low Density Lipoprotein (LDL) Subfractions in Microgravity),
APCF-Lysozyme (Advanced Protein Crystallization Facility - Testing New Trends in Microgravity Protein Crystallization),
APCF-Octarellins (Advanced Protein Crystallization Facility - Crystallization of the Next Generation of Octarellins),
APCF-PPG10 (Advanced Protein Crystallization Facility - Protein Crystallization in Microgravity, Collagen Model (X-Y-Gly) Polypeptides - the case of (Pro-Pro-Gly) 10),
APCF-Rhodopsin (Advanced Protein Crystallization Facility - Crystallization of Rhodopsin in Microgravity),
ARIS-ICE (Active Rack Isolation System - ISS Characterization Experiment),
ARISS (Amateur Radio on the International Space Station),
BBND (Bonner Ball Neutron Detector),
Brados (Acquisition of Data About the Radiological, Electromagnetic and Different Physical Environments on Board ISS, and Their Effects on the Safety of the Crew, Space Equipment and Materials),
Cardio-ODNT (Dynamics of the Main Factors of Cardiac Function, of Central and Regional Circulation in Rest and During the Influence of Lower Body Negative Pressure),
CardioScience (Study of Cardiovascular Deconditioning Under Weightlessness Conditions),
CBOSS-01-02-Renal (Cellular Biotechnology Operations Support Systems: Human Renal Cortical Cell Differentiation and Hormone Production),
CBOSS-01-Colon (Cellular Biotechnology Operations Support Systems: Use of NASA Bioreactor to Study Cell Cycle Regulation: Mechanisms of Colon Carcinoma Metastasis in Microgravity),
CBOSS-01-Ovarian (Cellular Biotechnology Operations Support Systems: Evaluation of Ovarian Tumor Cell Growth and Gene Expression),
CBOSS-01-PC12 (Cellular Biotechnology Operations Support Systems: PC12 Pheochromocytoma Cells - A Proven Model System for Optimizing 3-D Cell Culture Biotechnology in Space),
CEO (Crew Earth Observations),Clinical_Nutrition_Assessment (Clinical Nutrition Assessment of ISS Astronauts, SMO-016E),
Cogni (Cognitive Process for 3-D Orientation perception and Navigation in Weightlessness),
DCPCG (Dynamically Controlled Protein Crystal Growth),
Diatomeya (Stability of Geographical Position and Configuration of Borders of Bioproductive Water Zones of the World Oceans, Observations by Orbition Station Crews),
Diurez (Fluid and Electrolyte Metabolism and Hormonal Regulaltion of Fluid Volume),
DREAMTiME (DREAMTiME),
EarthKAM (Earth Knowledge Acquired by Middle School Students),
Environmental Monitoring (Environmental Monitoring of the International Space Station),
ESA-GCF (European Space Agency - Granada Crystallisation Facility),
EXPPCS (EXPRESS Physics of Colloids in Space),
Farma (Characteristics of Pharmacological Responses (absorption, distribution and elimination of acetominophene) in Long Duration Space Flight),
Glidoproteid (Extraction and Investigation of surface glycoproteins E1-E2 Alphavirises on Earth and in Space),
H-Reflex (Effects of Altered Gravity on Spinal Cord Excitability),
Identifikatsia (Identification of the Sources of Dynamic Loads on ISS ),
Imedias (Observation of Environmental Phenomena),
Inflight Education Downlinks (International Space Station Inflight Education Downlinks),
Interactions (Crewmember and Crew-Ground Interaction During International Space Station Missions),
Iskazheniye (Determination and Analysis of Magnetic Interference on ISS),
ISS Acoustics (International Space Station Acoustic Measurement Program),
Izgib (Effect of Performance of Flight and Science Activities on the Function of On-Orbit Systems on ISS (Mathematical Model)),
Kromka (Verification of the Effectiveness of Devices for the Protection of the Exterior Surface of ISS from Contaminants Deposited by Pulsed Cycling of Liquid-Jet),
Meteoroid (Recording Meteoroidal and Technogenic Particles on the External Surface of the Service Module of the Russian Segment of ISS),
Mimetik-K (Crystalization of antigen Binding Fragment of Monoclonalical Antibody to Glucosaminilmuramildepeptide),
MISSE and 2 (Materials International Space Station Experiment - 1 and 2),
Paradont (Condition of Peridontal Tissues in Space Flight),
Plasma Crystal (Dusty and Liquid Plasma Crystals in Conditions of Microgravity),
Privyazka (Development of High Precision Orientation of Scientific Devices in Space with Reports of Deformation of the ISS Hull),
Profilaktika (Mechanisms of Action and Influence, and Effectiveness of Various Methods of Phrophylaxis Directed Toward Prevention of Disturbances of the Human Locomotion System in Weightlessness),
Prognoz (Development of a Method of Operational Prediction of Work Load on Crew Piloting Objectives),
PuFF (The Effects of EVA and Long-Term Exposure to Microgravity on Pulmonary Function),
Renal_Stone (Renal Stone Risk During Spaceflight: Assessment and Countermeasure Validation),
SKR (Skorpion: Development and Acquisition of Multifunctional Control-Measurement Device for Controlling the Environment of Scientific Experiments Inside a Pressurized Station),
Sprut-MBI (Determination of Intracellular and Extracellular Fluid Volume in Humans in Space Flight),
Subregional_Bone (Subregional Assessment of Bone Loss in the Axial Skeleton in Long-term Space Flight),
Tenzor (Definition of Dynamic Characteristics of ISS),
Uragan (Hurricane: Experimental Development of Groundbased System of Monitoring and Predicting the Progression of a Naturally Occurring Technogenic Catastrophe),
Vektor-T (Study of a High Precision System for Prediction Motion of ISS),
Vzglyad (Photographing the Interior of ISS),
Xenon1 (Effect of Microgravity on the Peripheral Subcutaneous Veno-Arteriolar Reflex in Humans).

The Expedition Three crew of the International Space Station enjoyed a unique view of the 2001 Leonid meteor storm. "It looked like we were seeing UFOs approaching the earth flying in formation, three or four at a time," recalls astronaut Frank Culbertson. "There were hundreds per minute going beneath us, really spectacular!" News reports had warned sky watchers in advance: On November 18, 2001, Earth was due to plow through a minefield of debris shed by Comet Tempel-Tuttle. Innumerable bits of comet dust would become meteors when they hit Earth's atmosphere at 144,000 miles per hour (64,000 m/s). Experts predicted an unforgettable display ... and it came. Millions of people saw the show, but only three of them—the ones on board the space station—saw it from above. "We had to look down to see the meteors," says Frank Culbertson. "That's because the atmosphere (where comet dust burns up) is below the station."

Common work with the visiting crew of Soyuz TM-33 (October 23, - October 31, 2001) was done.