Launch from Cape Canaveral (KSC); landing on Cape Canaveral (KSC).

It was the first time since ASTP that a Russian cosmonaut was onboard of an U.S.- spacecraft. STS-60 was the first mission of the US/Russian Shuttle-MIR Program. The deploying of the Wake Shield Facility failed several times. Possible was only a flight on the Remote Manipulator Arm of the shuttle. Experiments in biology and biomedicine in the Spacehab-module were done: Three-Dimensional Microgravity Accelerometer (3-DMA) experiment, Astroculture Experiment (ASC-3), Bioserve Pilot Lab (BPL), Commercial Generic Bioprocessing Apparatus Experiment (CGBA), Commercial Protein Crystal Growth Experiment (CPCG), Controlled Liquid Phase Sintering (ECLiPSE-Hab), Immune Response Studies Experiment (IMMUNE-01), Organic Separation Experiment (ORSEP), Space Experiment Facility (SEF), Penn State Biomodule (PSB) and the Space Acceleration Measurement System (SAMS) Experiment. Sergei K. Krikalyov had been operating the SAMS experiment.

The crew deployed the small German-Built Bremsat-Satellite on February 09, 1994. It was developed by the Bremen University and build by Firma OHB-System and performed environment observations.