Launch from Cape Canaveral (KSC); landing on Cape Canaveral (KSC).

With STS-60 the first time since ASTP a Russian cosmonaut was onboard of an U.S.- spacecraft. STS-60 was the first mission of the US/Russian Shuttle-MIR Program. The mission carried the Wake Shield Facility experiment and a SPACEHAB module into orbit, and carried out a live bi-directional audio and downlink link-up with the cosmonauts aboard the Russian space station MIR.

The deploying of the Wake Shield Facility failed several times and all WSF operations only took place at the end of the RMS and there would be no WSF free-flying operations on the mission.

Experiments in biology and biomedicine in the Spacehab-module were done: Three-Dimensional Microgravity Accelerometer (3-DMA) experiment, Astroculture Experiment (ASC-3), Bioserve Pilot Lab (BPL), Commercial Generic Bioprocessing Apparatus Experiment (CGBA), Commercial Protein Crystal Growth Experiment (CPCG), Controlled Liquid Phase Sintering (ECLiPSE-Hab), Immune Response Studies Experiment (IMMUNE-01), Organic Separation Experiment (ORSEP), Space Experiment Facility (SEF), Penn State Biomodule (PSB) and the Space Acceleration Measurement System (SAMS) Experiment. Sergei K. Krikalyov had been operating the SAMS experiment.

The crew successfully deployed the small German built Bremsat satellite on February 09, 1994. It was developed by the Bremen University and build by company OHB-System and performed environment observations.