Launch from Cape Canaveral (KSC); landing on Cape Canaveral (KSC). Low cloads at Cape Canaveral and bad weather at the emercency landing places forced a scrub on June 20, 1993.

The crew retrieved the European built platform EURECA (deployed on mission STS-46 in summer 1992). It was stowed in the payload bay of the orbiter Endeavour.

The only EVA in this mission was performed by David Low and Peter Wisoff on June 25, 1993 (5h 50m), to make final tests for repairing works on the Hubble Space Telescope. An improperly installed electrical connector on Endeavour's Remote Manipulator System (RMS) arm (installed 180 degrees off its correct position) prevented EURECA from recharging its batteries with orbiter power. A flight rule requiring anntenna stowage was waived and EURECA was lowered into the payload bay without latching its antenna. Mission Specialists David Low and Peter Wisoff safely secured EURECA's dual antennas against the science satellite. After David Low could gently push the arms against EURECA's latch mechanisms, payload controllers then drove the latches to secure each antenna.

In the remaining time of the mission, the crew worked on experiments in the Spacehab module in the Shuttle's lower deck. These experiments included studying body posture, the spacecraft environment, crystal growth, metal alloys, wastewater recycling and the behavior of fluids. Among the experiments was an evaluation of maintenance equipment that may be used on the ISS. The diagnostic equipment portion of the Tools and Diagnostics System experiment was performed by Nancy Sherlock. Using electronics test instruments including an oscilloscope and electrical test meter, Nancy Sherlock conducted tests on a mock printed circuit board and communicated with ground controllers via computer messages on suggested repair procedures and their results.

Due to bad weather at Cape Canaveral the landing was delayed 24 hours.