Launch from the Baikonur Cosmodrome; landing 59 km northeast of Arkalyk.

Soyuz TMA-3 carried the ISS expedition 8 The mission was called a "caretaker" crew. Following a two day solo flight Soyuz TMA-3 docked to ISS on October 20, 2003. Aleksandr Kaleri and Michael Foale replaced the expedition 7 crew.

The expedition 8 crew conducted the first two-person spacewalk at the International Space Station. Unlike previous spacewalks conducted by ISS crews, there was not a crewmember inside the Station as the spacewalkers worked outside. The spacewalk was based out of the Pirs docking compartment. The spacewalkers wore Russian Orlan space suits.

The only EVA in this mission was performed by Michael Foale and Aleksandr Kaleri on February 26, 2004 (3h 55m) to install new experiments and replace and remove parts for existing experiments on the exterior of the ISS. The EVA was shortend due of cooling problems with Aleksandr Kaleris space suit.

Among other repair work the crew later repaired successful a treadmill and an oxygen producing Elektron unit aboard the ISS. The crew also performed all in all 27 experiments on different scientific fields.

During her stay on board of the ISS the crew of expedition 8 carried out the following scientific experiments:
Actin (Role of Weightlessness on Metabolism),
ADUM (Advanced Diagnostic Ultrasound in Microgravity),
ARISS (Amateur Radio on the International Space Station),
BCAT-3-4-CP (Binary Colloidal Alloy Test - 3 and 4: Critical Point),
BCAT-3-BA (Binary Colloidal Alloy Test - 3: Binary Alloys),
BCAT-3-SC (Binary Colloidal Alloy Test - 3: Surface Crystallization),
Biodegradation (Initial stage of Biodegradation and Biodeterioration in Space),
Bioekologia (Generation of High Efficiency of Microorganisms for the Production of Preparations of Biodegradable Oil, Organophosphorus Material, Measures for the Protection of Plants, as well as, of Exopolysaddharides Uses in the Petroleum Industry),
Biorisk (Influence of Factors of the Space Environment on the Condition of the System of Microorganisms-Hosts Relating to the Problem of Environmental Safety of Flight Techniques and Planetary Quarantine),
Biotest (Biochemical Status of Humans in Long Duration Space Flight),
Brados (Acquisition of Data About the Radiological, Electromagnetic and Different Physical Environments on Board ISS, and Their Effects on the Safety of the Crew, Space Equipment and Materials),
Caf (Crystalization of th Protein Caf1M and its Combination with the Terminal Peptide Caf1 as the Elements for the Development of a New Generation of Antimicrobial Medicinal Preparations and Components of Vaccines from Yeasts),
Cardio-ODNT (Dynamics of the Main Factors of Cardiac Function, of Central and Regional Circulation in Rest and During the Influence of Lower Body Negative Pressure),
CBOSS-FDI (Cellular Biotechnology Operations Support Systems: Fluid Dynamics Investigation),
CEO (Crew Earth Observations),
Chromosome-1 (Chromosomal Aberrations in Blood Lymphocytes of Astronauts-1),
Clinical Nutrition Assessment (Clinical Nutrition Assessment of ISS Astronauts, SMO-016E),
Diatomeya (Stability of Geographical Position and Configuration of Borders of Bioproductive Water Zones of the World Oceans, Observations by Orbition Station Crews),
Diurez (Fluid and Electrolyte Metabolism and Hormonal Regulaltion of Fluid Volume),
EarthKAM (Earth Knowledge Acquired by Middle School Students),
Environmental Monitoring (Environmental Monitoring of the International Space Station),
EPO (Education Payload Operations),
EPO-Demos (Education Payload Operation - Demonstrations),
ETD (Eye Tracking Device),
Farma (Characteristics of Pharmacological Responses (absorption, distribution and elimination of acetominophene) in Long Duration Space Flight),
Foot (Foot Reaction Forces During Space Flight),
Gematologia (Morphofunctional Characteristic of Blood Cells and the Intensity of Erythropoiesis in Humans by the Influence of Factors of Space Flight),
Heart (Physiological Parameters that Predict Orthostatic Intolerance After Spaceflight),
HPA (Hand Posture Analyzer),
ICE-First-Aging (International Caenorhabditis elegans Experiment First Flight-Aging),
ICE-First-Apoptosis (International Caenorhabditis elegans Experiment First Flight-Apoptosis),
ICE-First-Cells (International Caenorhabditis elegans Experiment First Flight-Cells),
ICE-First-Development (International Caenorhabditis elegans Experiment First Flight-Development),
ICE-First-Genomics (International Caenorhabditis elegans Experiment First Flight-Genomics),
ICE-First-Muscle Proteins (International Caenorhabditis elegans Experiment First Flight-Muscle Proteins),
ICE-First-Radiobiology (International Caenorhabditis elegans Experiment First Flight-Radiobiology),
Identifikatsia (Identification of the Sources of Dynamic Loads on ISS),
Inflight Education Downlinks (International Space Station Inflight Education Downlinks),
Interactions (Crewmember and Crew-Ground Interaction During International Space Station Missions),
Interleukin-K (Production of Hight Quality Crystals of Interleukin -1Alpha, -1Beta and Receptor of Antagonist of Interleukin-1),
Iskazheniye (Determination and Analysis of Magnetic Interference on ISS),
ISSI (In Space Soldering Investigation),
ISS Acoustics (International Space Station Acoustic Measurement Program),
Izgib (Effect of Performance of Flight and Science Activities on the Function of On-Orbit Systems on ISS (Mathematical Model)),
JAXA-GCF (Japan Aerospace and Exploration Agency - Granada Crystallization Facility High Quality Protein Crystallization Project),
Journals (Behavioral Issues Associated with isolation and Confinement: Review and Analysis of Astronaut Journals),
Kromka (Verification of the Effectiveness of Devices for the Protection of the Exterior Surface of ISS from Contaminants Deposited by Pulsed Cycling of Liquid-Jet),
Meteoroid (Recording Meteoroidal and Technogenic Particles on the External Surface of the Service Module of the Russian Segment of ISS),
Mezhkletochnoe Vzaimodeistvie (Intercellular Interactions in Space Flight),
MFMG (Miscible Fluids in Microgravity),
Mimetik-K (Crystalization of antigen Binding Fragment of Monoclonalical Antibody to Glucosaminilmuramildepeptide),
MISSE-1 and 2 (Materials International Space Station Experiment - 1 and 2),
Mobility (Promoting Sensorimotor Response Generalizability: A Countermeasure to Mitigate Locomotor Dysfunction After Long-Duration Space Flight),
Molniya-SM (Investigation of Lightning Discharges in the Earth's Atmosphere and Lower Ionosphere),
MOP (Motion Perception: Vestibular Adaptation to G-Transitions),
MSK (Cultivation of Mesenchymal Stem Cells From Bone Marrow in Space Flight),
Muscle (Study of Low Back Pain in Crewmembers During Space Flight),
Paradont (Condition of Peridontal Tissues in Space Flight),
PCG-STES-RGE (Protein Crystal Growth-Single Locker Thermal Enclosure System-Regulation of Gene Expression),
PCG-STES-SA (Protein Crystal Growth-Single Locker Thermal Enclosure System-Science and Applications of Facility Hardware for Protein Crystal Growth),
PFMI (Toward Understanding Pore Formation and Mobility During Controlled Directional Solidification in a Microgravity Environment),
Pilot (Individual Characteristics of Psychophysiological Regulatory Status and Reliaility of Professional Activities of Cosmonauts in Long Duration Space Flight),
Plasma Crystal (Dusty and Liquid Plasma Crystals in Conditions of Microgravity),
Platan (Search for Low Energy Heavy Particles of Solar and Galactic Origin),
Privyazka (Development of High Precision Orientation of Scientific Devices in Space with Reports of Deformation of the ISS Hull),
Profilaktika (Mechanisms of Action and Influence, and Effectiveness of Various Methods of Phrophylaxis Directed Toward Prevention of Disturbances of the Human Locomotion System in Weightlessness),
Prognoz (Development of a Method of Operational Prediction of Work Load on Crew Piloting Objectives),
Pulse (Vegatative (Autonomic) Regulation of the Cardio-Respiratory System of Humans in Conditions of Weightlessness),
Rastenia (Growth and Development of Higher Plants through Multiple Generations),
Relaksatia (Processes of Relaxation in the Ultraviolet Band Spectrum by High Velocity Interaction of Exhaust Products on ISS),
Renal Stone (Renal Stone Risk During Spaceflight: Assessment and Countermeasure Validation),
Sample (Study of Microbial Communities Exposed to Weightlessness),
Seeds (Seeds in Space),
SKR (Skorpion: Development and Acquisition of Multifunctional Control-Measurement Device for Controlling the Environment of Scientific Experiments Inside a Pressurized Station),
SPHERES (Synchronized Position Hold, Engage, Reorient, Experimental Satellites),
Sprut-MBI (Determination of Intracellular and Extracellular Fluid Volume in Humans in Space Flight),
Subregional_Bone (Subregional Assessment of Bone Loss in the Axial Skeleton in Long-term Space Flight),
Tenzor (Definition of Dynamic Characteristics of ISS),
Toksichnost (Development of a Metod of Express Monitoring of Toxicity of Water in Space Flight),
Uragan (Hurricane: Experimental Development of Groundbased System of Monitoring and Predicting the Progression of a Naturally Occurring Technogenic Catastrophe),
Vaktsina-K (Structural Study of Protein Candidats in a Vaccine for AIDS on Earth and in Space),
Vektor-T (Study of a High Precision System for Prediction Motion of ISS),
Yeast-GAP (Yeast-Group Activation Packs).

Pedro Duque landed on October 28, 2003 at 02:40 UTC with Soyuz TMA-2 spacecraft.