Launch from Cape Canaveral (KSC); landing on Cape Canaveral (KSC). The launch was scheduled for November 11, 1995 but was cancelled due to bad weather.

Following a two day solo flight the Atlantis docked with MIR on 15.11.1995. It was the second docking with the MIR space station. A docking adapter was as payload in the cargo bay and was leaved on MIR. Joint scientific work with 20th resident crew of the MIR. During the three day docking, the Russian, Canadian and American astronauts transferred various supplies from Atlantis to MIR, moved several long-term experiments, pieces of equipment and manufactured products from MIR to the Atlantis. After three days of common flight, separation and returning home.