Launch from Cape Canaveral (KSC); landing on Edwards AFB.

ASTRO-2 was the second dedicated Spacelab mission to conduct astronomical observations in the ultraviolet spectral regions. It consists of three unique instruments - the Hopkins Ultraviolet Telescope (HUT), the Ultraviolet Imaging Telescope (UIT) and the Wisconsin Ultraviolet Photo-Polarimeter Experiment (WUPPE). These experiments will select targets from a list of over 600 and observe objects ranging from some inside the solar system to individual stars, nebulae, supernova remnants, galaxies and active extragalactic objects.

On the Middeck, science experiments include the Protein Crystal Growth Thermal Enclosure System Vapor Diffusion Apparatus-03 experiment (PCG-TES-03), the Protein Crystal Growth Single Thermal Enclosure System-02 (PCG-STES-02), the Shuttle Amateur Radio Experiment-II (SAREX-II), the Middeck Active Control Experiment (MACE), the Commercial Materials Dispersion Apparatus Instrumentation Technology Associates Experiments-03 (CMIX-03) and the Midcourse Space Experiment (MSX).

The mission was extended one day due of bad weather and so this Shuttle flight became the longest to date.