Launch from Cape Canaveral (KSC); landing on Cape Canaveral (KSC); ISS Assembly Flight 9A. During the launch first time a small color video camera was used, which was mounted on the External Tank and which broadcasted excellent live views until seperation of the SRBs.

Mail goal of STS-112 was to deliver the 28,000 pound Starboard 1 (S1) truss segment to the Space Station. The S1 truss segment, which provides structural support for the Space Station.

Following a two day solo flight Atlantis docked with the ISS on October 09, 2002 and common work with the fifth expedition of the ISS was done.

The first EVA was performed by David Wolf and Piers Sellers on October 10, 2002 (7h 1m) to attach power, data and fluid connections between the newest segment of the station's backbone - The Starboard One (S1) Truss and the first (SO) Truss segment. Using the Canadarm2 robot arm Sandra Magnus and ISS-5 crewmember Peggy Whitson positioned the S1 at the starboard end before. David Wolf and Piers Sellers also deployed an antenna und released restraints on a handcar.

The second EVA by Piers Sellers and David Wolf occured on October 12, 2002 (6h 4m), in which they continue outfitting the S1-truss to bring it to life. They connected ammonia cooling system lines and mount another external video camera package on the hull of the Unity node, among other works.

The third and final EVA was again performed by Piers Sellers and David Wolf on October 14, 2002 (6h 36m) to complete the installation and checkout of the newly installed truss segment.

STS-112 also carried several science experiments to the station including the Plant Generic Bioprocessing Apparatus (PGBA), Commercial Generic Bioprocessing Apparatus (CGBA), the Protein Crystal Growth Single-locker Thermal Enclosure System housing the Protein Crystallization Apparatus for Microgravity (PCG-STES-PCAM) and samples for the Zeolite Crystal Growth Furnace (ZCG) experiment.