Launch from Cape Canaveral (KSC); landing on Cape Canaveral (KSC); ISS Assembly Flight 9A. During launch first time using of a small color video camera, which was mounted on the External Tank and which broadcasted excellent live views until seperation of the SRBs.

Following a two day solo flight Atlantis docked with the ISS on 09.10.2002 and common work with the ISS expedition 5.

First EVA by Wolf and Sellers on 10.10.2002 (7h 1m) to attach power, data and fluid connections between the newest segment of the station's backbone - The Starboard One (S1) Truss and the first (SO) Truss segment. Using the Canadarm2 robot arm Magnus and ISS-5-crewmember Peggy Whitson positioned the S1 at the starboard end before. Wolf and Sellers also deployed an antenna und released restraints on a handcar.

Second EVA by Sellers and Wolf on 12.10.2002 (6h 4m), in which they continue outfitting the S1-truss to bring it to life. They connected ammonia cooling system lines and mount another external video camera package on the hull of the Unity node, among other works.

Third and final EVA again by Sellers and Wolf on 14.10.2002 (6h 36m) to complete installation and checkout of the newly installed truss segment.

STS-112 also carried several science experiments to the station including the Plant Generic Bioprocessing Apparatus (PGBA), Commercial Generic Bioprocessing Apparatus (CGBA), the Protein Crystal Growth Single-locker Thermal Enclosure System housing the Protein Crystallization Apparatus for Microgravity (PCG-STES-PCAM) and samples for the Zeolite Crystal Growth Furnace (ZCG) experiment.