Launch from Baikonur; landing 140 km northeast of Dzheskasgan.

The original launch date of November 21, 1988 was moved back to permit French president François Mitterrand to attend the launch.

Second joined mission USSR - France. Following a two day solo flight the Soyuz docked with the MIR-Kvant-complex on 28.11.1988. Scientific work with third resident crew. Volkov and Krikalyov together with Polyakov became the fourth resident crew. EVA by Volkov and Chrétien on 09.12.1988 (5h 57m), installing the 240 kg French ERA experimental deployable structure and a panel of material samples. Chrétien became the first non-American and non-Soviet cosmonaut to perform a spacewalk.

During this mission experiments in 16 different fields were performed as topografic and spectrografic research of the Earth surface, biological and medical research (incl. Blood and heart tests).

Chrétien landed on 21.12.1988 at 09:57 UT with Soyuz TM-6-spacecraft.