Launch from Baikonur; landing 69 km northeast of Arkalyk.

Seventh resident crew of MIR spacestation. Scientific work (astrophysical, geophysical, Earth observation, space materials science, biological and biotechnological research and experiments) performed in the Soyuz TM-10-Kvant-MIR-Kvant2-Kristall complex. But they also had to do maintenance and repairing work. Supplies with cargo space ships Progress M-4 and M-5; EVA on 29.10.1990 (3h 45m) repairing work on damaged hatch of Kvant-2-module (only partly successful).

When returning to Earth, Japanese cosmonaut Akiyama (launched with Soyuz TM-11-spacecraft) onboard.