Launch from the Baikonur Cosmodrome; landing 69 km northeast of Arkalyk.

Following a two day solo flight Soyuz TM-10 docked with the MIR space station on August 03, 1990. The cosmonauts became the seventh resident crew of MIR space station. Scientific work (astrophysical, geophysical, Earth observation, space materials science, biological and biotechnological research and experiments) was performed in the Soyuz TM-10-Kvant-MIR-Kvant2-Kristall complex. But they also had to do maintenance and repairing work. Supplies arrived at the spacestation with the cargo space ships Progress M-4 and M-5. Progress M-5 arrived at the station on September 29, 1990. It carried television equipment for the upcoming joint Soviet-Japanese mission. It was also the first Progress-M equipped with a Raduga return capsule.

The only EVA in this mission was performed on October 29, 1990 (3h 45m). Gennadi Manakov and Gennadi Strekalov removed thermal insulation. They found that the hatch was beyond their ability to repair. They attached a device to the hatch to allow it to close properly.

When the crew returned to Earth, Japanese cosmonaut Toyohiro Akiyama (launched with Soyuz TM-11 spacecraft) was onboard.