Launch from Cape Canaveral (KSC); landing 370 km southwest of San Diego in the Pacific Ocean.

Second crew of Skylab space station. Scientific work, including medical research and solar observation; test with a new developed "chair"; observation of the behavior of small animals (spiders and fishes) in the microgravity. EVAs: by Garriott and Lousma on 06.08.1973 (6h 31m), Garriott and Lousma on 24.08.1973 (4h 30m), Bean and Garriott on 22.09.1973 (2h 41m). They conducted repairing work on the station (deploying twin pole solar shield) and replaced film cartridges for solar camera.

Leaks in Apollo CSM thrusters led to preparation of a rescue mission, but later on it was decided to attempt a landing with the faulty thrusters. The crew was in better condition after landing, than the Skylab 2 crew. New flight duration record. The recovery ship was the USS New Orleans.