Launch from Cape Canaveral; landing 1130 km southeast from Cape Canaveral in the Atlantic Ocean.

Gemini 12 was the final Gemini mission. The major objectives of this mission were nearly the same as for Gemini 11, but they were more successful. In preparation for this mission, new, improved restraints were added to the outside of the capsule, and a new technique underwater training was introduced, which would become a staple of all future spacewalk simulation.

The docking with the unmanned Agena target vehicle GATV-12 was successful, even there were problems with the rendezvous radar. For the second time, a Gemini crew was able to practice docking and undocking. The climb to a higher orbit, however, was cancelled because of a problem with the Agena booster. There was also a malfunction with the fuels cells in the Gemini capsule.

Buzz Aldrin performed three EVAs during one flight, which was a new record. The first (stand-up EVA) was on November 12, 1966 (2h 29m) in which he photographed starfields, installed a movie camera, fixed the new handrails and retrieved a micrometeorite collection package. He did his work very calm and became not exhausted. The second spacewalk, an umbilical EVA, was performed on November 13, 1966 (2h 06m), in which he attached a 100-foot tether from the GATV to the spacecraft docking bar and evaluated various restraint systems. The final EVA, again a stand-up EVA, was performed on November 14, 1966 (0h 55m), in which he snapped several ultraviolet photographs of constellations.

It was again an automatic controlled reentry, only 5,5 km far from the recovery ship, the carrier USS Wasp.