Launch from the Baikonur Cosmodrome; landing 150 km northwest of Tselinograd.

Soyuz 22 was launched to orbit September 15, 1976 at the unusually high inclination of 64.75°, not used since the Voskhod program. The orbiting Salyut 5 space station was at the standard 51.8° inclination, which led some observers to conclude that this solo Soyuz mission was chiefly intended to observe NATO's Exercise Teamwork, taking place in Norway, well above 51° latitude and therefore outside of good visual range of the space station. However, the particular camera used, an MKF-6 multi-spectral Carl Zeiss camera which allowed six simultaneous photographs to be taken, suggested to others that reconnaissance, if part of the mission, was a minor part of it. Soyuz 22's orbital inclination maximized ground coverage, especially of the former East Germany. There were two orbit changes within 24 hours of launch. The first came on the fourth orbit and changed the orbit to 280 by 250 kilometres (170 by 160 mi). The second, on the sixteenth orbit, circularized the orbit to 257 by 251 kilometres (160 by 156 mi).

The mission's stated objectives were to "check and improve scientific and technical methods and means of studying geological features of the Earth's surface in the interests of the national economies of the Soviet Union and the German Democratic Republic."

The vehicle was the modified ASTP back-up ship. The ASTP docking mechanism was replaced with an GDR built Carl Zeiss-Jena multi-spectral camera. One cosmonaut would control the operations of the camera from inside the Orbital Module while the second changed the orientation from the Descent Module. The camera had six lenses, four visible light and two infrared, which imaged a preselected 165 km (103 mi) -wide strip of the Earth's surface. This allowed over 500,000 km2 (190,000 sq mi) to be imaged in 10 minutes.

The first test images from the camera were of Baikal-Amur railway that was being constructed. On the third day of the mission the crew took photographs of Siberia to the Sea of Okhotsk in the morning and the northwestern USSR.

On the fourth day, the crew imaged the Moon rising and setting to investigate the Earth's atmosphere. This also allowed them to see how clean their spacecraft's windows were. They also imaged Central Asia, Kazakhstan, and Siberia, with attention to geological formations and agricultural effects.

The fifth day focused on Azerbaijan, the southern Urals, the Baikal-Amur railway again, and western Siberia. At the same time a second camera was being flown on an aircraft over the same areas in order to compare the images.

The sixth day saw images of Siberia, the Northern USSR, and European USSR which were, according to TASS, areas that had never before been "targets of space photography."

The last full day had the crew focus on East Germany, where an An-30 aircraft was flying carrying an identical camera to the one aboard Soyuz 22. They also re-photographed Central Asia, Kazhakstan, eastern Siberia, and the southwestern USSR in order to compare images with those taken earlier in the mission. One of the tasks the crew undertook was to dismantle the camera in order to remove its color filters needed to calibrate the images back on Earth. The task took them several hours to complete.

The crew also performed several biological experiments. They ran a small centrifuge in the orbital module to see how plants grew in artificial gravity. They also investigated the effects of cosmic rays on human vision. This effect had first been reported by Apollo astronauts who described bright flashes when they closed their eyes. This was due to cosmic rays passing through the eye. Soyuz 22 also carried a small aquarium so that the crew could watch the behavior of fish.